Cantor Fitzgerald rates Madrigal Pharma stock Neutral ahead of Rezdiffra launch By Investing.com

On Friday, Cantor Fitzgerald initiated coverage on Madrigal Pharmaceuticals (NASDAQ:) with a Neutral rating. The firm’s assessment of Madrigal is based on the anticipated market performance of its drug candidate Rezdiffra, an oral THR-beta agonist aimed at treating MASH, a liver condition. The analyst pointed to the results of a survey involving 30 US specialists, indicating a positive near-term uptake for Rezdiffra among MASH physicians.

Despite the promising early reception, the analyst noted that current full-year projections for Rezdiffra’s performance in 2024 and 2025 are consistent with the consensus estimates. However, they expressed concern that the consensus forecasts beyond 2025 might be overly optimistic, failing to account for potential risks such as emerging competition and the outcomes of ongoing Phase 3 clinical trials.

The analyst also addressed the intellectual property landscape for Rezdiffra, acknowledging that while the composition of matter patent expires in 2026, the drug is further protected by polymorph patents expiring in 2033. This IP protection could secure a substantial revenue period into the late 2030s. Yet, the firm’s stance aligns with the market’s current understanding.

For Madrigal’s market capitalization, which exceeds $8 billion, to see significant growth, the analyst believes that Rezdiffra’s market launch would need to surpass consensus estimates for several consecutive quarters. As this outcome is not anticipated at present, the analyst has decided to commence with a Neutral stance on the stock.

The survey conducted by Cantor Fitzgerald included 15 hepatologists and 15 gastroenterologists, who collectively treat over 13,000 MASH patients annually, including more than 6,000 with F2-F3 stage MASH. This survey was intended to assess early launch trends and long-term uptake potential for Rezdiffra in the MASH treatment landscape.

In other recent news, Madrigal Pharmaceuticals has announced significant developments. The company’s shareholders approved an amendment to its 2015 Amended Stock Plan, increasing the number of shares for issuance by 750,000 and extending the plan’s duration by 10 years. This move aligns with the company’s incentive awards recovery policy and aims to boost performance and align employee interests with those of shareholders.

Analyst firms have weighed in on Madrigal Pharmaceuticals’ prospects. Wolfe Research initiated coverage with an Outperform rating, projecting potential revenues of $4.6 billion in the F2-F3 patient population. However, BofA Securities commenced coverage with an Underperform rating, while H.C. Wainwright maintained a Buy rating despite lowering its price target for the company.

Piper Sandler reaffirmed its Overweight rating, expressing optimism for the company’s prospects in 2024. These are the recent developments in the company’s journey.

InvestingPro Insights

Madrigal Pharmaceuticals (NASDAQ:MDGL) has been the subject of various analyst ratings, with Cantor Fitzgerald recently initiating coverage with a Neutral stance. As investors consider the future of Madrigal and its drug candidate Rezdiffra, there are several financial metrics and expert insights from InvestingPro that may shed light on the company’s current status and outlook.

InvestingPro data indicates that Madrigal Pharmaceuticals holds a market capitalization of $6.05 billion, a significant figure that reflects investor confidence in the company’s potential. However, the company’s P/E ratio stands at -12.14, with an adjusted P/E ratio for the last twelve months as of Q1 2024 at -13.5, underscoring the current lack of profitability. Moreover, the firm’s Price/Book ratio during the same period is 7.05, which is considered high and may suggest the stock is valued richly relative to its book value.

InvestingPro Tips reveal that Madrigal’s stock price often moves in the opposite direction of the market, which could be an important consideration for investors seeking to diversify their portfolio or hedge against market movements. Additionally, it’s noteworthy that Madrigal holds more cash than debt on its balance sheet, providing a level of financial stability that could be reassuring to investors in times of uncertainty.

For those interested in deeper analysis and additional insights, InvestingPro offers more tips on Madrigal Pharmaceuticals, which can be accessed at https://www.investing.com/pro/MDGL. Moreover, users can benefit from an exclusive offer by using the coupon code PRONEWS24 to get an additional 10% off a yearly or biyearly Pro and Pro+ subscription, allowing them to stay ahead with comprehensive financial data and expert analysis.

Investors should note that there are 13 additional InvestingPro Tips available for Madrigal Pharmaceuticals, which provide a broader perspective on the company’s financial health and market position. These insights could be particularly valuable for those looking to make informed decisions about their investment in Madrigal.

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