H.C. Wainwright gives Summit Therapeutics stock Buy rating on ivonescimab’s promise By Investing.com

On Monday, H.C. Wainwright initiated coverage on Summit Therapeutics plc (NASDAQ:) stock, a clinical-stage biopharmaceutical company, with a Buy rating and a 12-month price target of $16.00 per share.

The firm’s lead asset, ivonescimab, is currently in development for the treatment of various cancers and has shown promise in early comparisons to existing treatments.

Ivonescimab is a tetravalent bispecific antibody that targets both programmed cell death protein 1 (PD-1) and vascular endothelial growth factor (VEGF), which are key in cancer treatment.

The dual engagement of these targets through a single molecule has demonstrated potential advantages over the combination of separate PD-1 and VEGF inhibitors.

Summit Therapeutics’ approach with ivonescimab includes a cooperative binding mechanism, a daisy chain effect that may enhance T cell binding, and a lowered off rate for sustained target engagement.

These features have led to promising top-line data from Summit’s partner, Akeso, in a study conducted in China. The study showed that ivonescimab was superior to Merck & Co.’s Keytruda, a leading PD-1 inhibitor, in a head-to-head trial for first-line non-small cell lung cancer (NSCLC) treatment. Keytruda has been approved in 40 indications and generated over $25 billion in global sales in 2023.

The positive outlook for ivonescimab, along with its comparison to the commercial success of Keytruda, has led H.C. Wainwright to suggest that Summit Therapeutics’ market capitalization of approximately $7.5 billion undervalues the company if ivonescimab continues to prove its superiority. The firm’s coverage initiation highlights the potential of Summit Therapeutics’ lead asset in the competitive oncology market.

InvestingPro Insights

As Summit Therapeutics (NASDAQ:SMMT) garners attention with its promising ivonescimab for cancer treatment, InvestingPro data and tips shed light on the company’s financial health and market performance. With a market capitalization of $7.81 billion, Summit’s valuation reflects significant investor interest. However, the company’s P/E ratio stands at -40.82, indicating that it is not currently generating profits, a sentiment echoed by analysts who do not expect profitability this year. This aligns with the broader financial picture, as the company has an adjusted operating income of -$143.7 million over the last twelve months as of Q2 2024.

InvestingPro Tips highlight the stock’s high price volatility and its tendency to move in the opposite direction of the market, which could be significant for investors looking for non-correlated assets. Additionally, Summit has shown strong returns over the last year, with a 526.74% price total return, a figure that far outpaces many competitors in the biopharmaceutical sector. These returns are particularly notable given the company’s weak gross profit margins and the absence of dividend payments to shareholders.

For those considering an investment in Summit Therapeutics, it’s worth noting that the company has liquid assets that exceed its short-term obligations, suggesting a level of financial stability in the near term. Moreover, the company operates with a moderate level of debt, which may offer some reassurance to risk-averse investors. While the stock is trading at a high Price/Book multiple of 40.04, indicating a premium on its assets, the strong historical returns could be a compelling factor for certain investment strategies.

For more in-depth analysis and additional InvestingPro Tips, interested parties can explore https://www.investing.com/pro/SMMT, which lists 14 more tips for potential investors to consider.

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